Papillary Thyroid Cancer: the most common type of thyroid cancer. However, that information will still be included in details such as numbers of replies. Current analysis of thyroid biopsy results cannot differentiate between follicular or hurthle cell cancer from noncancerous adenomas. Hi, I am joining this group because I was recommended surgery.. Christmas got in the way, so January 22 is my date. 2021 Apr;10(2):168-173. doi: 10.1159/000509037. I was doing some research and came across the Afirma Thyroid Analysis by Veracyte and was wondering if anyone in a similar situation had tried this and what there results were. I was told that my thyroid needs to be removed (at least half, possibly all). HHS Vulnerability Disclosure, Help -No Size changes of Nodule in last 2-3 months (duration of time to get all of these tests) I could feel food getting lodged in my throat, and felt a pinch like a nerve at times, too. Molecular Markers: genes and microRNAs that are expressed in benign or cancerous cells. These results do not change the risk of malignancy of the (ROM) of the Afirma GSC suspicious result." This isn't saying that Afirma's test isn't useful. Sorry for such a long post, but as Im sure you remember, those first few days after receiving this type of news, Im full of questions and anxiety. One of the hardest things about all of this is the adjustment. Ultrasound reports unfortunately not very informative other than size. 8600 Rockville Pike However, its relatively low positive predictive value (PPV) limited its use as a classifier for patients with suspicious results. This all new to me and I have a lot to learn. https://www.inspire.com/groups/thyca-thyroid-cancer-survivors-association/discussion/afirma-thyroid-analysis/. The result of this 2.1 cm Bethesda IV nodule A is Arma GSC Benign, which suggests a low risk of cancer at approximately 4%. benign), 25% of cases had follicular variant papillary thyroid cancer, 2% of cases had classical papillary thyroid cancer and 8% of cases had follicular thyroid cancer. So I thought I was in the clear, and decided to just monitor this nodule for growth, and revisit the surgery idea only if size became an issue. The panel includes genes that have been identified In this discussion of the Afirma test from 2013 on this board several people also had false results from the Afirma test all false suspicious except for the first, reply from member dacooper12 who said that the Afirma test said her nodule was benign but later she had her thyroid removed and found out that it was actually pap cancer that spread into her central lymph node. Of the 16 cases of follicular variant papillary thyroid cancer, 14 of them were noninvasive follicular variant of papillary thyroid cancer (88%). He tried to console me but he was also upset. A woman on the excellent health site Medhelp told me she had a 3cm. eCollection 2021. I don't understand the results , I thought that if the result is Benign it means you have no cancer genes and it is 95% sure you won't get cancer . I hope this helps calm some fears for others who may be going through the same thing. So, if you were going to go down that route then this will save you from having a second biopsy. Hello, new here and confused, anxious and a bit worried. The aim of this study was to determine the clinical performance of the GSC as compared with the GEC at one academic medical center. Several thyroid nodules. Bugs me. The Afirma GSC is a cancer rule-out test with a high negative predictive value so that cytologically indeterminate (Bethesda III/IV)2thyroid nodules with an Afirma GSC benign result can be considered for clinical observation in lieu of diagnostic surgical resection (Fig. I almost want to cancel the surgery. I understand that Afirma tends to have a lot of false positives, but it's supposed to be fairly accurate for negative results. With each step, I'd expected to hear, "yeah, you are a lumpy person, but no cancer." I didn't make a big deal about the cost because I am having surgery and they money I paid was my 20% co-pay and my out of pocket limit is almost met. And the 3rd test was Afirma which came back "suspicious". May 7 endocrinologist Dr.Bryan Mclver,one of the authors of the article from September 2012 in The American Thyroid Association's Journal called,An Independent Study Of A Gene Expression Classifier (Afirma) In The Evaluation Of Cytologically Indeterminate Thyroid Nodules Initial Report and he used to work at The Mayo Clinic,(he now works at The Moffit Cancer Center called me back. BACKGROUND I was informed in August of 2013 after a FNA that one of my nodules was suspicious and the recommendation was a TT. 2017 May;125(5):313-322. doi: 10.1002/cncy.21827. Good luck and happy thoughts! Finally, the cells were sent to Afirma, Now I was growing concerned. On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). I am so new to all this that I don't know what this means. What do I do? Epub 2018 Apr 10. The Affirma Xpression Atlas is based on RNA sequencing. However, researchers found that when the Afirma GSC identified a thyroid nodule with a TSHR mutation as suspicious, the risk of malignancy was 15.3%, a level of risk for which most physicians. Afirma GSC is a pre-operative genomic test for thyroid tumor biopsies that have . (The office had already explained that benign results would be sent in a letter, but suspicious or confirmed cancer results would warrant a phone call.) This study suggests that more research is needed to determine if the noninvasive follicular variant thyroid cancer can be diagnosed by molecular markers without proceeding to surgery. http://www.thyroidboards.com/showthread.php? If all nonsurgical GEC benign cases were actually benign, when evaluating the cases that had surgery, the chance that a GEC suspicious nodule was actually cancer was 33.3% and the chance that a GEC benign nodule was actually benign at surgery was 98.2%. I'm curious, if you had similar biopsy results and had surgery, was your final path malignant or not? Anyone here have a false NEGATIVE Afirma GEC result? I have 1.6 cm nodule on my right lobe. I hadn't told my two college-age daughters about the series of more and more concerning doctor's visits, but knew I couldn't get through a long day with them at home without showing my emotions. The aim of this study was to find out how often indeterminate thyroid biopsy specimens which were read as suspicious by the GEC test were ultimately diagnosed as noninvasive follicular variant papillary thyroid cancer after surgery. The aggressive one wants to cover his ass in the tiny chance you have an aggressive thyroid cancer, and the wait and see one is playing the odds that there is nothing to worry about, and that unneeded surgery has risks that are higher than the benefits in your case. She says very little, and if she does say anything, questions my reactions. There are four types of FVPTV: encapsulated with invasion, encapsulated without invasion, unencapsulated non-invasive and unencapsulated and invasive into the surrounding parenchyma of the gland. Thank you. Like she was just trying to tie up loose ends, and I happened to be one of those loose ends. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. The Xpression Atlas reports 905 genomic variants and 235 fusion pairs on GSC Suspicious, Suspicious for Malignancy (SFM), and Malignant FNA samples at the time of diagnosis. After some research of my own, I decided to leave it. undefined will no longer be visible to you including posts, replies, and photos. Thyroid cancer support group and discussion community. One such test is the Afirma gene test. The results were suspicious of papillary cancer, but not conclusive. All my blood tests and tsh levels are in the normal range. WHAT ARE THE IMPLICATIONS OF THIS STUDY? Just had TT yesterday. Repeat Fine Needle Aspiration Cytology Refines the Selection of Thyroid Nodules for Afirma Gene Expression Classifier Testing. Federal government websites often end in .gov or .mil. I've read a lot about this test (both good and bad). This site needs JavaScript to work properly. Thanks so much! They were incredibly supportive and also concerned. All I can say is that in reviewing my ultrasounds and the report from the interventional radiologist and the Affirma report, I have noticed that there are inconsistencies in even the reported measurements of the nodules and now that I have read further into studies done on people undergoing thyroid removal after getting "Suspicious"/40% of Cancer Affirma results, there are many more false positives than Afirma would have you understand. My surgeon wants to operate right away stating that these kind of results have a 90% truancy for cancer to be present. Afirma; FNA; cytology; thyroid nodules. It just really annoys me that doctors can order tests that cost us money without our consent. On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). Please, I am looking for any and all thoughts. Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. https://www.inspire.com/groups/thyca-thyroid-cancer-survivors-association/discussion/genetic-test-two-different-results/reply/6888430/?msg_activity=reply_posted. Wong KS, Angell TE, Strickland KC, Alexander EK, Cibas ES, Krane JF, Barletta JA. Upenn top thyroid pathologists including Dr.Virginia Lavosi report that follicular neoplasms with oncocytic (hurthle cells)often are misclassified as suspicious by the Afirma test! Can someone give me their take on my fna results? My question is then I guess, is it really that bad afterwards managing levels and the other side effects post TT? Follow-up of atypia and follicular lesions of undetermined significance in thyroid fine needle aspiration cytology. http://biotechstrategyblog.com/2012/06/veracyte- afirma-gene-expression-classifier-thyroid-cancer- diagnostic-test.html/ I'm sure that over the years as more people have this Afirma test done,there will be even more people posting on thyroid and general health boards about getting false "suspicious" results from it! Our offering enables physicians to answer multiple clinical questions for their thyroid patients using a single, minimally invasive fine needle aspiration (FNA) sample. And he said he doesn't think the Afirma test is as accurate as they say. Then in December 2014 I thought to have it checked again, with the same results although this time I had it send for the Afirma testing which I was told is more accurate test for cancer. Found an endocrinologist who is willing to work with me on some more testing. It's pretty difficult being the patient trying to sort this all out. Epub 2020 Aug 6. Papillary thyroid cancer is the most common type of thyroid cancer. I have bumps on my head that come and go and are considered normal, and another cyst on my arm that I've had since I was eleven -- also normal. BACKGROUND Thyroid nodules are commonly found on ultrasound of the neck and the evaluation of a thyroid nodule may include thyroid biopsy. The GSC correctly identified 41 of 45 malignant samples as suspicious, yielding a sensitivity of 91.1%, and 99 of 145 . Which means I would still be paying this amount to the hospital if I didn't pay it to Affirma. Overall malignancy rates were highest in the GSC group at 39%, compared to 20% and 22% in the no-molecular-testing and GEC groups, respectively (P = 0.0222) . Don't want to gain weight or feel less optimal then I am now. But, I'm also tired of living with the uncertainty and semi-annual nerve sessions after each ultrasound. Most probably, a lot more lobectomies are going to be performed for indeterminate nodules since the level of certainty is going to drop. She also said that her endo said that all of his colleagues stopped using this test and that in their experience the number of suspicious that came back cancerous is the same as what you find in the general population. I'm a foodie who has always struggled with weight, but I also exercise so I'm always just plump but in otherwise decent health. Of the 164 nodules included in the study with the GSC test, suspicious nodules were found in 39 of the 164 nodules (23.7%). This was done in hopes of maintaining my own thryoid function which the doctors and I felt better than taking thyroid medicine daily for the rest of my life. One has tested benign on several FNAs, is cystic, and has remained consistent in size. After reading many stories, I didn't know what to expect. He later called and said he was sending me for a biopsy. MeSH My oldest daughter has a friend who has survived thyroid cancer, and SHE was sure to tell ME about that. The mindset of most surgeons is to cut it out - ignoring the risks of that approach. The Afirma GEC is a microarray-based molecular test that uses a machine learning-derived classification algorithm to further classify indeterminate thyroid nodules into benign and suspicious categories. Thyroid 2016;26:911-5. At the end of his great article in the journal Clinical Thyroidology August 2012 criticizing the inaccuracies and unreliabilities of the Afirma test, endocrinologist of 50 years Dr.Jerome Hershman says, Currently the Veracyte Affirma GEC method "retails" for 3,350 plus 300 for cytopathology. sharing sensitive information, make sure youre on a federal He then says, However,another interpretation is that the method can be used only to classify a nodule as benign and the "suspicious" category by GEC should not be used. Still, I can see my nodule on one side and don't want to risk having cancer in my body, so I was ready to set up the surgery as soon as possible. I find out my biopsy results next week. Wong KS et al. I am not afraid of the surgery, only would really be disapointed if a vital organ was removed from my body for nothing. Results: Cancer Cytopathol. These results show an improved accuracy for the GSC as compared with the GEC. Many endocrinologists have written articles in The American Thyroid Association's journal criticizing the inaccuracies and unrelabilities of this recent Afirma test, the strongest criticism and concern is by endocrinologist of (*50* years!) Now can anyone shed some light on any negative effects of RAI on your body in the long-run? For some reason, my long time best friend is one of the least supportive in all of this. Like I said I'm doing ok and compared to what I see about the aftermath of having my thyroid removed, I sometimes just want to leave it alone and keep an eye on it instead. I had the ultrasound, and am waiting for my appointment with her to go over the images. He said this Afirma test is wrong half the time misclassifying benign nodules as suspicious,(I'm sure it's even more than half!) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. I have slightly high blood pressure and slightly high cholesterol that are well controlled with meds. That not only had the nodule continued to grow (from 2.0 to 3.2cm over the last 2 years), but it is now showing increased central vascularity. doi: 10.1210/jendso/bvab148. Thanks. It is unclear whether mutations in these genes cause the cancer or are just associated with the cancer cells. The remaining 18% were malignant. Molecular markers: genes and microRNAs that are expressed in benign or cancerous cells. The original Afirma Xpression Atlas (XA) panel reported on 761 genomic variants and 130 fusion pairs from 511 genes ( 6 ). 2) Partial or Total Thyroidectomy? I was just feeling so much weight and defeated as a mother of four small children..three biological and one adopted in 2012..could not phantom the idea of not being there for my kids esp. A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, THYROID CANCER This occurs in 1520% of biopsies and often results in the need for surgery to remove the nodule. What should I know? -5.5cm x 3.9cm x 3.9cm Left Thyroid Nodule: Large mixed/mostly solid, isoechoic, ill-defined margins, macrocalcifications, taller-than-wide: TI-RADS 5 She has other small nodules on her other thyroid lobe. He recently called me back and said that my criticism of the test is valid. 1. Thanks again, Ok so this is all brand new to me so please bear with me. The cells need to be "fresh." Thyroid Nodules: https://www.thyroid.org/thyroid-nodules/. ThyCa: Thyroid Cancer Survivors' Association, Inc. Dr.Jerome Hershman. I'm fearful this is a Hurthle Cell Lesion, and I do not like what I have read. official website and that any information you provide is encrypted I tried to avoid it for 10 years I am 52 years old , I have a multinodular goiter with many, many , many nodules,the biggest on the left side 2.2 cm right side 2.6 all TSH test results are good , in fact , my thyroid is fonctioning perfectly well. Dincer N, Balci S, Yazgan A, Guney G, Ersoy R, Cakir B, Guler G. Cytopathology. Abigail. Anyway, if these are to be become non-malignant, the rates of malignancy for the different Bethesda Categories are going to have to be adjusted downward. Hello. After hearing this, I felt a huge kick in my gut and also stupid for getting a second opinion for a fine needle biopsy though I'd ended up with an endo, who wrote articles on the subject. I'm determined to eek out the positive in this. Adherence to Active Surveillance and Clinical Outcomes in Patients with Indeterminate Thyroid Nodules Not Referred for Thyroidectomy. I have found this community very informative, thank you. Accessibility Advice needed please. But in my case, it was a risk well worth taking. This process has helped me to realize that there is a lot that physicians do not understand--much more than I knew. Among the 25 papers that approached Afirma GEC, four studies enrolled an additional number of 635 TNs from 596 patients to evaluate the Afirma GSC (16, 17, 57, 70). Epub 2020 May 21. and I said this is not a good test,and he said I don't think it's a good test either! So I was reading about the new kind of fna biopsy called Afirma, and I guess that my question is, is it worth getting it as a second opinion or should I go through with the surgery because of the results not being undetermined. I found many people including more than a few on the Inspire site in their ThyCa forum who have unfortunately gotten false suspicious results from this test and as a result had totally unnecessary thyroid surgery,including this poor woman on thyroidboards.com who is the worst case I found so far,the Afirma test told her she had an 80% highly suspicious result and because of this her endocrinologist told her to expect cancer and that she had an 80% likelihood that her solid hypoechoic 1- 1 1/2 cm mildly suspicious as follicular neoplasm nodule was cancer,so she had totally unnecessary thyroid surgery for a benign nodule and was scared to death for nothing! He wisely advised that I need a thyroid ultrasound which revealed the nodule had grown to 2.2cm. microRNA: a short RNA molecule that has specific actions within a cell to affect the expression of certain genes. What was your experience? However, the results are not conclusive. But it is saying that actual surgical results show that 40% "suspicion" turns out to send lots of people to surgery and then about 50% of the surgeries done yield results that show that the nodules were not cancerous at all. I feel good for 55 and slid through menopause easily. FOIA Epub 2017 Feb 2. I asked her if I have permission to email and post these articles and she said yes,they are for the public. Paratracheal nodule (inclduing B1FS): Thyroid Parenchyma, negative for tumor. On May 8th endocrinologist Dr.Steven P.Hadak who with Dr. David S. Rosenthal co-authored one of these studies for The American Thyroid Association's Clinical Affairs Committee called,Information For Clinician's:Commercially Available Molecular Diagnosis Testing In The Evaluation Of Thyroid Nodule Fine-Needle Aspiration Specimens called me back and was very nice,he even had a patient waiting! Now, I will most probably undergo surgery, I requested only the right side be removed and they will have a pathologist look at it while I am under and then decide if they remove the whole thing. These gene patterns are better at ruling out thyroid cancer in an indeterminate nodule than confirming cancer. 2013 Dec;24(6):385-90. doi: 10.1111/cyt.12021. Have lots of decisions to make and just trying to do some homework. The rest were called benign by the GEC. The .gov means its official. National Library of Medicine Cancer-Associated Genes: these are genes that are normally expressed in cells. Follicular Neoplasm. The good news is that if your insurance refuses to pay for the test, then you will only have to pay 300.00 out of pocket. I know how frustrating, scary and expensive this whole process is.I am sorry that you are going through it!! I was told the only way to find out for sure is to have half my thyroid removed. I had my surgery in NYC, it took 2 hours, and I went home the same day. Patient medical records were retrospectively reviewed for clinical history, FNA results, radiologic findings, management and follow-up. Sometimes you only hear the bad stories and not the good so I wanted to share mine. Noninvasive follicular variant of papillary thyroid carcinoma and the Afirma gene-expression classifier. I'm a lumpy person, I told my husband. and transmitted securely. Partially Encapsulated Follicular Variant of Papillary Carcinoma. The cancer-associated genes important in thyroid cancer are BRAF, RET/PTC and RAS. Fingers crossed they come back negative for cancer! He recently emailed me back and said,as we discusssed on the phone,he agrees with many of my concerns about the Afirma test. (although it is so small, you can see it in my neck). My doctor then sent me to an endocrinologist for a biopsy which came back with atypical but inconclusive results. Clinician should therefore exercise caution in using this result for treatment decisions. I called back and left them a message that was at home, to call me back. Home Patients Portal Clinical Thyroidology for the Public February 2020 Vol 13 Issue 2 p.13-14, CLINICAL THYROIDOLOGY FOR THE PUBLIC The other side is that I had to have a 2nd biopsy done just to collect cells for AFIRMA. And it keeps growing. government site. Right now my neck lymph nodes look good. So now I feel I have no choice to take it out (the nodule also grew .5 cm since the Aug test). Genes hold the information to build and maintain an organisms cells and pass genetic traits to offspring. But all of these suspicious ultrasound results have me wondering if I might have gotten a false negative on the Afirma. Follicular and hurthle cells are normal cells found in the thyroid. I just wrote that these are 25% of all thycas, but I have read just recently that the figure might be anywhere between 15-25% because there are varying standards for diagnosing these between different institutions. I am so glad to find this as reading everyone's story helps me feel not so aloneTHANK YOU! Among the 22 with only a TP53 alteration, the first 16 consecutive nodules were included (7 nodules were Bethesda III and 9 nodules were Bethesda IV). The range of confirmed cancer (post surgery) from different studies was as low as 17% to as high as close to 50%. Neither will talk to the other. Indeterminate Thyroid Biopsy: this happens a few atypical cells are seen but not enough to be abnormal (atypia of unknown significance (AUS) or follicular lesion of unknown significance (FLUS)) or when the diagnosis is a follicular or hurthle cell lesion. My expensive, unsolicited, Afirma test results came back as negativegood thing I had already had my TT before I received the results; I have stage III pap/follicular thyca. The Afirma GSC is a cancer rule-out test with a high negative predictive value so that cytologically indeter-minate (Bethesda III/IV)2 thyroid nodules with an Afirma GSC benign result can be considered for clinical observation in lieu of diagnostic surgical resection (Fig. I am hesitant to go to surgery with the 30% cancer chance without more information. A. And is this what that recent October 2015 WSJ article was hinting at.having people with certain types of cancer of the thyroid not undergo surgery at all but just adopt a wait and see posture? Thyroid cancer is found in ~5% of thyroid nodules, so the vast majority are benign (noncancerous). The authors concluded that a GEC suspicious test result may include noninvasive follicular variant papillary thyroid cancer as well as classical papillary thyroid cancer. :-). The surgeon was great. I called my husband before I even received the callback, and couldn't stop crying. It's barely even hoarse. Negative for BRAF, RET/ptc1 and ptc3 Thoughts or experiences?? I wasn't one to resist. Are you sure you want to block this member? http://www.glandsurgery.org/article/view/1002/1193 Biotech Strategy Blog in this post by Pieter Droppert June 28,2012 Also mentions 48% of nodules falsely called "suspicious" for cancer and can cause many people to have unnecessary thyroid surgery when they don't have cancerous thyroid cells! In early September, at a well-woman visit, my primary care doctor found a lump in my neck and sent me for a sonogram that found three nodules -- one estimated at 3.5 cm, one at 1.5 cm and the third much smaller. They call follicular neoplasms with hurthle cells FNOF. Surgical margins: negative for tumor (tumor is < 0.1cm from margin) There was no follow up in 13% of cases and 87% were resected (50% lobectomies and 50% total thyroidectomies). Since that time, the pain has all subsided -- I think the biopsy just roughed things up, but when they calmed down, I felt no pain whatsoever, again. The third biopsy was sent for genetic testing which came back as suspicious. A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, THYROID NODULES So far, no problems with calcium. I had another biopsy which came back showing "Atypical cells". Afirma result was suspicious in 69 cases. Results: Thirty-eight TP53 variants were present among >13,000 Bethesda III/IV Afirma GSC Suspicious samples. She also said that her surgeon also had 5 other patients that had the Afirma test done,and said their nodules were suspicious too and they all were found to benign after they were removed! -FNAB Result: Predominantly Hurthle Cells, Abundant Macrophages, Colloid and Bloody Background: Bethesda 3 (FLUS/AUS) My AFIRMA is also 40% risk. Mine did, and that can also be a sign of cancer. Anyone have AUS nodule with suspicious Afirma results end up cancerous? Bookshelf THE FULL ARTICLE TITLE While most thyroid nodules are non-cancerous (Benign), ~5-10% are cancerous. For one thing, I had some pain on one side after biopsy. 5. The doc mentioned the thyroid and upon a physical exam felt the nodule, leading to the rest of the testing. The main goal was to help decide if my "suspicious for neoplasm" nodule was benign or not. All thyroid nodules with a "suspicious" Afirma GEC result were investigated. So I gather if I am reading what you reported correctly, your case is another false NEGATIVE for the Afirma test? For the past year I've been seeing functional medicine doctors to see if I could shrink my nodules with diet and nutrition but when I got the positive Afirma test and the biggest nodule 3cm kept growing I finally decided to have surgery, which I had last Thursday. Thyroid fine needle aspiration biopsy: a simple procedure that is done in the doctors office to determine if a thyroid nodule is benign (non-cancerous) or cancer. I wanted to share my Thyroidectomy story because like most of you I was super scared and nervous about surgery but my surgery went great and I've had no complications. I regard this as a substantial cost for it's possible contribution to avoiding diagnostic surgery,in part because it also misclassifies lesions as suspicious about half the time. I know, that is still pricey but seems cheap compared to $6,000. Each of my pre-surgical tests are pointing more and more in the wrong direction. Indeterminate thyroid biopsy: this happens a few atypical cells are seen but not enough to be abnormal (atypia of unknown significance (AUS) or follicular lesion of unknown significance (FLUS)) or when the diagnosis is a follicular or hurthle cell lesion. Because of this rather benign course, some pathologists have even questioned whether this subgroup is a cancer after all. The Affirma Genomic Sequence Classifier (GSC) is based on DNA sequencing. Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. There are risks and benefits to any decision - and humans are very bad at assessing both. My Endo thinks I should see a thyroid surgeon and my other doctor wants to repeat ultrasounds in 4 months, adopting a wait and see approach. GEC's SE and SP among studies ranged from 78.0 to 100% and 7.7 to 51.7%, respectively. I'm not against surgery if needed, but wondering shouldn't it be followed for a bit before such a drastic measure is taken. The PPV was 50% among GSC suspicious nodules when a variant or fusions was identified, compared with 44% among GSC suspicious nodules when no variant or fusion was identified (p = 0.77 [2]).
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